Tuesday, July 17, 2012

Be the Tiger Woods of Investing: Beat Everybody Else By Avoiding ...

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As I?m coming back from vacation, I asked Paul from Capital Manifesto to write this guest post about investing behaviors. I can relate to this article as in the past two years, my dividend stock picks did very well but I wasn?t able to avoid ?the Big Miss?. My two trades on RIM (2011) and on VNP (2012) were two ?Big Miss? and brought my whole portfolio down. The funny part is that I?m a similar golfer; I?m doing well overall but I?m always trying to do THE shot that will make my game exciting? or make a triple bogey!

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Many people always want to know what the best way to get great returns are.? Of course, they are looking for that one magic bullet that will make their portfolio or other investment sparkle and outperform all of their friends.? Unfortunately, it NEVER works that way because as one investment gets hot, other investments will start to lag and vice versa.? It?s just the way the cookie crumbles, much like everything else in life.

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I recently read the controversial book by Tiger Woods? ex-coach, Hank Haney. He spoke that when he coached Tiger, and other golfers like Mark O?Meara, he always tried to teach them to avoid ?the big miss? while playing golf.? For those of you golfers out there, this is usually that one horribly errant drive or bunker shot that could make an easy par or bogey into a disastrous triple bogey, or worse.? If you have one or two per round, which is a problem I used to have until I got professional lessons, it can mess up your game, your mind, your confidence, and then you will wonder why you even play.? Same with investing: If you have your steady investments but every so often you have that ONE or TWO laggards that really drag your portfolio, you will seem like you are never gaining ground on retirement. It can be demoralizing.? So the key is to avoid ?the big miss? in investments, just like in golf or any other sport you may play.

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To continue with the golf analogy, many people know that Tiger Woods has been a dominant force in golf since he arrived in 1996.? Yes, he is going through problems now, but even this year he has won two events and seems to have his game coming back.? When Tiger was dominating year after year, if you look at his stats, he only average 0.5 to 1.5 strokes per round better than his best peers yet he dominated even the #2 ranked guys because if you add up 0.5 or 1 stroke per round to a four round tournament, it added up to a lot of strokes and a lot of wiggle room.

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Warren Buffett is our Tiger Woods in the investment world.? He has racked up 20%+ returns since the 1960s and if you look at his yearly performance, he rarely has down years. In fact, I believe he has only had 2 down years in all of those years.? Does he have some major advantage over everyone else?? I think he does NOW because everyone brings him the best deals.? But back in the 1960s and 1970s, when he was crushing even 20% returns, he had the same information as other people in his group but he assessed investments differently.? He looked at the base value and if he understood the business and the moving parts, he was willing to invest.? Too often, even ?expert? investors chase returns and that is where problems happen. Usually when returns become hot, that is when they are poised to have problems. It goes back to my article on the volatility index, when everyone is happy and optimistic is usually when things are ripe for a correction and vice versa. Is this set in stone? Of course not?

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?But look at other events of the past: Tech stocks of the late 1990s and real estate of the 2000s.? When those sectors were hopping and popping, no one could find a bad investment and no one could say why any investment should be looked at cautiously.? You have to be able to break every investment down into its basic form. If you don?t feel comfortable with the outcome, avoid it.? This is how you can gain an edge of a few percentage points per year. Look at historic trends in investing, such as the fact that dividend paying stocks have routinely beat the S&P 500 overall by 2-3% per year for decades.? If you averaged 2% per year for 30 years on top of the S&P 500, you would have over double the amount of money than if you just matched the S&P 500 return which is already considered a pretty good benchmark!

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I don?t have the secret investment advice to get you your edge consistently over time.? What I can say is that understanding and avoiding what you have a gut feeling is incorrect is a good way to start investing.? Avoid ?the big miss? by avoiding what your golf buddy or neighbor is telling you to invest in because this may only cost you a percent or two per year, but if you save that, as you saw in my last paragraph, you would be able to retire with over double the amount of money than following the fun trends.

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Paul Gabrail is an investor who prefers to focus on the realistic aspects of the economy. He is never hesitant to offer his oftentimes unique perspective on all matters related to the economy, real estate and personal finance.

He co-founded Select Investment Group, a real estate investment firm that owns and manages 800 rental unit properties and $60 million in assets. He?s also a partner at MGO, a private wealth management firm with more than $400 million in managed assets. For more articles and thoughts like this, you can visit his blog www.thecapitalistmanifesto.com or follow him on Twitter @capmanifesto.

You are interested in dividend investing? Check out my Free Dividend Investing eBook and don't forget to sign-up to my RSS Feeds!

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Source: http://www.thedividendguyblog.com/2012/07/16/the-big-miss/

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Monday, July 16, 2012

Classic Camping Games For Families |

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Camping games are all a part of creating the fun atmosphere you want during your excursion. If you are about to head out on a family camping trip, plan ahead and grab a few simple supplies. You won?t have to think too hard about new games when so many classics exist. Here are what we consider some of the top family camping games:

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Capture the Flag

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A team effort is going to be the only skill that gets you through this game. Capture the Flag has been played by generation upon generation of campers. While there are various sets of rules and regulations to play by, depending on how serious you are about the game, the basics are this;

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You have two teams, each with a different color flag, which is simply a piece of fabric. A red bandana and a blue bandana works well. Each team has two objectives; 1) capture the other team?s flag and return to their home base, and 2), keep their flag from being captured. Set up the rules of game before beginning. For instance, the game is won when one team successfully captures the flag three times, return to their home base and defend the capture for two minutes.

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Skits

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Always a highlight of camping trips, skits bring a certain comedic nature to the camp site. Pick a fun topic, or poke some fun at your family and try your hand at impressions while other family members try to guess who you are. Then, if you want it to be a competition, judge your skits on different areas of excellence, like funniest, most dramatic, or even most accurate impression. Be sure to create silly trophies to bring along.

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4 Square

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A big bouncy ball and four squares is all you need. Draw one large square in the sand or grass, using a stick or some chalk, or even some water-based paint, then divide it into four squares. Each player gets a square (or if you have more than four players, the extras wait to stand in for players who miss and are out of the game.) Decide on the rules, then flip a coin or play rock-paper-scissors to choose a server. Then get in your squares and start bouncing the ball to each other, trying to make your opponents miss. When they miss, they?re out. Pretty soon it will trickle down to a playoff between two players, scrambling to knock the other out of the game.

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Dodge Ball

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To play this game you?ll need to set up a rectangular court with a center-line defined, and a big, soft foam coated rubber ball for each player. Divide your players in even numbers at either end of the court and place the balls in a line along the center-line. Have someone outside the teams blow a whistle. Then players rush in, grab a ball, and run back to their own starting line. Turn around and face your opponents and throw the ball toward the players (head shots are discouraged!), hitting them in the belly or back. This eliminates an opponent and sends them to the sidelines. Pick up another ball (they?ll be rolling all over the place) and aim at another opponent. If they actually catch your ball, then you are out instead. Every time an opponent gets sent to the sidelines, one of the players on your team can re-enter the game. The game is over when it comes down to two players and one is taken out with the ball. Just remember; everyone has their own idea for rules, so be sure to agree on court rules before the game begins.

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Tug of War

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Depending on the number of people in your camp, you can either create a two-team tug of war or a three-team tug of war. Most of us are familiar with the two-team style ? a long rope place over a line, or even a puddle. To create a three-team tug of war, just tie your long rope into a circle and divide it evenly into thirds, forming a triangle when each team grabs hold of the rope. Now you have three teams fighting against two opponents. Maybe two of the teams will decide to ?gang up? on one team when push comes to shove? or tug!

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Hot Potato

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You only need music that can be started and stopped easily, and a tennis ball or an actual potato to toss. Everyone playing gets in a circle, with one person holding the ball. Then someone outside the circle, with their back to the players, starts the music and the players toss the ball back and forth until the music player stops the music. The person left holding the ?hot potato? is out of the game. The game continues until it comes down to two players and they have a play off. The last person standing without holding the ?hot potato? is the winner. Stock up on fun prizes to encourage competition. This is a game that can be played with any number of players (2 or more), inside or outside, and at almost any age. If the players are old enough to toss and catch, they are old enough to play.

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Quiet Games

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Planning for rainy days or quiet times is a must to make a camping excursion successful. Camping while it rains can get boring quickly, unless you are prepared. Many card games and board games can be used for those times when running around outside won?t do. Uno, Hearts, Crazy Eights, and Go Fish are classics that almost everyone will either know how to play or be able to learn quickly. Board games like Life are very popular with many ages. Simple crafts are another idea for kids to stay busy and entertained indoors. If you don?t want to add to your cleanup chores indoors, choose crafts that don?t involve paints or other messy items. Some paper plates, yarn, crayons, crepe paper, ribbon, and school glue can go a long way toward keeping kids happy and busy indoors.

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You don?t have to look far, or think too hard, to create a fun camping trip for your family. Planning beyond the food and tent is important if you want to keep your family entertained and longing to go back and do it again. These games are easy to carry out with just a little planning.

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Source: http://mymommyneedsalife.com/2012/07/16/classic-camping-games-for-families/

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dori cathartic: Barthcolp.com: Home Improvement @ SEOValidator.Net

Home Improvement, Appliances, Audio Video, Bath and Shower, Cabinets, Cleaning Tips and, Tools, Concrete, DIY, Doors, Electrical, Energy Efficiency, Feng Shui, Flooring, Foundation, Furniture, Green Living, Heating and Air Conditioning, Home, Inspections, House Plans, Interior Design and Decorating, Kitchen, Improvements, Landscaping Outdoor Decorating, Lighting, New, Construction, Painting, Patio Deck

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Source: http://dori-cathartic.blogspot.com/2012/07/barthcolpcom-home-improvement.html

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Saturday, July 14, 2012

"In Santa Monica, Calif., two friends looking to buy an iPhone were asked whether they were speaking..."

In Santa Monica, Calif., two friends looking to buy an iPhone were asked whether they were speaking Persian and promptly informed, ?I am sorry, we don?t sell to Persians.? In Sacramento, an Iranian-American man looking to buy Apple products for personal use mentioned that he was also thinking about buying an iPod for his nephew in Iran and was told he could not buy anything, even for himself. An Iranian student in Atlanta, and his Iranian-American friend, were not permitted to buy an iPhone after the friend, under questioning, mentioned that the student planned to return to Iran for the summer. Apple has not been taken over by xenophobes. The discrimination is one result of trying to enforce flawed and haphazard United States export controls against countries, like Iran, that are under sanctions. Retail employees are left to interpret and implement federal policy, and racial profiling results. At the moment, nearly all exports to Iran are prohibited. Traveling to Iran with items like computers and smartphones is illegal. Apple?s own policy, stated on its Web site, makes it very clear that its products can?t be sent there. But it is also illegal in the United States for a private company to discriminate against individuals based on race, color, religion or national origin under the Civil Rights Act. This protection extends of course to retail stores. Apple officials note that their diverse retail work force includes many multilingual employees ? including employees who speak Persian with customers ? and deny any discrimination. Apple also says that if employees ask customers how they plan to use a product, it is only to help meet their needs ? not to ensure compliance with export laws.

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Why Is Apple Discriminating Against Iranian-Americans? - NYTimes.com

Wait, I might be 0.092983847389274759% Iranian, am I now allowed to used their fetishized stuff? I?m telling you, sanctions do not help in ?otherthrowing? the regime?it only hurts the people. In fact, this outlawing Iranians from Apple product is complete racism. Oh wait, it?s called a humanitarian racist intervention, right?

(via overtheeventhorizon)

Source: http://theredhammerandsickle.tumblr.com/post/27166880225

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Remarks following the meeting of President Herman Van Rompuy with Prime Minister of Romania, Victor Ponta

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Source: http://www.consilium.europa.eu/press/press-releases/latest-press-releases/newsroomloaddocument.aspx?id=1823&lang=English&directory=en/ec/&fileName=131707.pdf

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Work from Home: Thriving World wide web Businesses | PyaarDosti ...

You will discover substantial quantity of people who wish to operate from home. The quantity one particular wish of quite a few parents is always to be able to remain at residence with their kids and nonetheless make a living. Although many individuals are unaware, you will discover a sizable quantity of existing function at residence web corporations that need help or folks can even develop their own.

The choice to work from house can be a major one. Several individuals may perhaps take a large quantity of time to contemplate this life changing step. It is crucial to remember that a large quantity of individuals who function from house don?t uncover the most beneficial enterprise ideal away. It may well take a number of distinctive companies or even a couple of years ahead of you could show a profit; having said that, working from house is often an entertaining opportunity that your complete household can benefit from.

There are a wide wide variety of world wide web corporations that enable folks to produce a profit from house. There are lots of parents or entrepreneurs who selling online via an auction website. Net shopping has drastically elevated previously few years and so has the popularity of on-line auction web pages. Promoting on a web-based auction web page can be a handy and relatively uncomplicated approach to create your own house online business enterprise. You will be charged a fee for listing and promoting your item. The amount of the fee will depend on which on the net auction site you might be applying.

This residence online organization notion is a single that many folks can do since it requires tiny experience. On the web auction web-sites have templates that you just fill in; hence, you are not essential to become experienced in web style or coding to sell. New or pre-owned merchandise will be sold on-line, just about anything will sell. An excellent technique to ascertain if this perform at household online organization will perform for you personally is by selling a number of items from about your home. For those who have any old children?s clothes, toys, property dcor, or movies that you simply no longer watch, think about selling them. You could possibly make a number of dollars and it will offer you the chance to make a decision if selling on the net could be a lucrative property internet company for you.

In addition to selling merchandise on line, internet style is a preferred household net business enterprise notion. In case you are inexperienced in web design, but have the willingness to discover, you will find a wide range of resources out there. On line assist and guides are accessible for internet style or it is possible to take a class at a local college. Internet design is really a common household net business that is growing in demand. Whether it be for business or private use, quite a few men and women are deciding that they need to have their very own internet page; having said that, many do not even know exactly where to start.

Operating from property is advantageous to parents with children or disabled men and women. It really is possible for just about any one to work from residence. The internet has opened up many doors to a wide wide variety of diverse people. A property online business is inside your reach, you just have to have the time along with the have to have to succeed.

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Source: http://pyaardosti.com/work-from-home-thriving-world-wide-web-businesses

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Marriage and Name Changes in the Land Title Office | BC Real ...

I heard a wonderful story from a client this week who had decided to propose to his girlfriend after he carried her ?over the threshold? in to the new home they had just bought?together?in Kelowna. The client asked me ?When we get married, do we have to file that change with the Land Title Office??

Steps to Name Changes in the Land Title Office:

  1. Obtain the??original?certificate of change of name or?marriage?certificate from the BC Vital Statistics Agency.
  2. Inform your lender of the change of name, they may require your lawyer to prepare a declaration that you have changed your name.
  3. Once Step 1 & 2 are complete, bring the original document to your lawyer who will verify your identity and will file the legal name change in the Land Title Office.

Will the wrong name on title prevent me from selling or re-mortgaging the property?

It might, identity verification is taken very seriously by Realtors, Mortgage Brokers, and Lawyers in the Province of British Columbia and these professionals will require proof that you have the legal capacity to sell your property.

So, when you legally change your name, it is recommended that you file the change of name in the Land Title Office as set out above.

Written by Peter Borszcz, a Kelowna Real Estate Lawyer and Kelowna Business Lawyer.?

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This entry was posted in Buyers, First Time Home Buyers, Land Titles and tagged kelowna lawyer, Kelowna Notary, kelowna real estate lawyer, Land Titles, Mobile Home, Tenancy Termination by Peter Borszcz. Bookmark the permalink.

Source: http://bcrealestatelaw.com/2012/07/13/marriage-and-name-changes-in-the-land-title-office/

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Friday, July 13, 2012

On Deck, a sports calendar for July 12 - Bangor Daily News

BASEBALL

Sunday Recreational Baseball

At Newton, Mass., Henry Baseball is looking for new players ages 16 to 45 to play Sundays at 11 a.m., games are finished by 2 p.m.; league also needs coaches and volunteers; contact Henry at 781-891-0621

LL World Series trip

At Millinocket, Millinocket Little League bus trip to 2012 Little League World Series in Williamsport, Pa., four-day, three-night trip, Aug. 16-19, opening weekend of LLWS, two days at LLWS and a stop at National Baseball Hall of Fame in Cooperstown, N.Y., on return trip; cost per person, based on hotel room occupancy: single $805, double $500, triple $395, quadruple $345, quintuple $315, includes roundtrip motorcoach, three nights hotel, transportation to and from stadium and admission to the Hall of Fame; LLWS admission is free; contact Brian Brown at 731-8053 or katahdinsports@aol.com

BASKETBALL

July 16-27

At Bangor, Bangor Hoops Summer Basketball Program, girls and boys camps, girls for grades 1-6, 7-12, boys for grades 3-4, 5-7, 8-12, at James Doughty School or Bangor High, $50 per week, need-based scholarships are available, contact Katie Herbine 624-1476 or Roger Reed 848-5136

Coyote Camp

At Old Town, Elementary School, Coyote Boys JamCamp July 16-20, 8:30 a.m.-2:30 p.m., open to boys entering grades 4-12, for fun and skill development, contact Brian E. McDormand, Old Town boys varsity basketball coach, 207-290-7641 or bmac195554@msn.com

Eagles Basketball Camps

At Bangor, Husson University, boys camp July 29-Aug. 2, girls camp Aug. 5-9, grades 3-9, $425 overnight, $375 day camp

?Bears ?n? Claws? Dinner

At Bangor, coach Richard Barron?s home, University of Maine women?s basketball team ?Bears ?n? Claws? dinner, July 19, 6-8 p.m. at choice of lobster or hamburger with potato salad, corn, desserts and drinks, $50 per person, those under 10 eat free from kids? menu, all proceeds benefit the Friends of Maine Women?s Basketball; contact Tracy Guerrette at tracyguerrette@umit.maine.edu or by phone at 207-581-1075.

CANOE RACING

Saturday, July 21

At Fort Fairfield, Forbes Landing on Aroostook River, Regatta on the Aroostook, canoe and kayak race, registration 3-4:30 p.m. 6.5 miles of flat water, $10 per person, for info contact 472-3882 or 227-6306

CYCLING

Sunday, July 22

At Fort Fairfield, Fort Fairfield Community Center, Spud Cycle Classic Bicycle Race, registration 8 a.m., 25- and 12-mile races start at the Blockhouse on Main Street, $15 per rider, for info contact 472-3882 or 227-6306

CHEERLEADING

Spirit Camp

At Orono, University of Maine Student Recreation Center, July 25-27, 9 a.m. to 3 p.m., grades 1-6, instruction will be provided by the University of Maine Cheerleaders; for more info, email Spiritcheercamp@aol.com, or call Tami Campbell at 862-3355.

FOOTBALL

Classes for Prospective Officials

At Bangor, ROTC Room, Bangor High School, Bangor Chapter of Maine Football Officials to hold classes for prospective officials, Tuesdays for 11 weeks at 7 p.m., starting Aug. 14; successful candidates will work middle school games next fall; call Alan Kochis at 989-4372 or Allan Snell at 835-4515

Brewer seeks coaches

Brewer Youth Football is looking for interested and experienced football coaches to potentially coach in its youth football program for grades 3-4 or 5-6; those interested may send notification

and contact information to brewerwitchesyouthfootball@yahoo.com

UMaine High School Day Camp

At Saco, Thornton Academy, University of Maine football team high school day camp, July 26, 4:30 p.m. to 8 p.m., $25 per person; Black Bear coaches will conduct drills and competitions, only equipment needed is cleats; to register or for more information, contact coach Shawn Demaray at shawn.demaray@umit.maine.edu; deadline is July 23; players must fill out medical and risk forms, available at GoBlackBears.com, and take them to the camp.

7-on-7 Camp

At Orono, University of Maine, Alfond Stadium, UMaine football team?s 7-on-7 High School Tournament, July 28, ?two-hand touch? event includes morning round-robin play and single-elimination playoffs in the afternoon, UMaine coaches will officiate; $150 per team, athletes should bring a lunch, snacks, footballs, a jersey, sneakers and cleats; no pads needed; cost includes UMaine t-shirt; to register or for information, contact coach Shawn Demaray at shawn.demaray@umit.maine.edu by July 20; players must fill out medical and risk forms and take them to the camp.

GOLF

July 23-27

At Winterport, Junior Golf Camp at Sonny?s Par 3 and Driving Range, ages 11-14, July 23-27, 8-11:30 a.m., golf fundamentals, rules and 9-hole tourney on final day, for info contact 223-5242 or visit sonnysrange.com

Friday, Aug. 3

At Rocky Knoll CC, Orrington, Brewer High School?s Class of 1967 Golf Scramble, 1-4 p.m., $25, prizes, tourney benefits BHS Scholarship Fund, alumni and friends welcome, sign up at Rocky Knoll or contact Lynn Hunt at 989-5876 or on the BHSClassof67 website

Saturday, Aug. 18

At Rocky Knoll CC, 7th annual John Bapst Hockey Boosters Golf Tournament, noon registration, 1 p.m. shotgun start, prizes, team entry of $300 includes carts, meals, mulligans, for more information, visit www.johnbapst.org or contact Melissa Harvey at 207-949-7535 or email mharvey1324@gmail.com.

ROAD RACING

Saturday, July 14

At Hermon, Hermon High School, 7th Annual Danforth?s to Dysart?s 5K Road Race and Blueberry Pie Challenge, 8 a.m. Fun Run ($5 half-mile), 8:30 a.m. 5K Walk ($15), 9 a.m. 5K ($15), for extra $10, run two miles, eat a piece of blueberry pie and finish race; race-day registration 7 a.m.; race benefits Hermon High cross country team

Saturday, Aug. 11

At Calais, 33rd Annual Johnson?s 5-Mile International Road Race, 9 a.m., contact the Calais Rec Department 454-2761 or calaisrec@calaismaine.org

Source: http://bangordailynews.com/2012/07/12/sports/on-deck-a-sports-calendar-for-july-12/

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Thursday, July 12, 2012

Transforming cancer treatment

Transforming cancer treatment [ Back to EurekAlert! ] Public release date: 11-Jul-2012
[ | E-mail | Share Share ]

Contact: Peter Reuell
preuell@fas.harvard.edu
617-496-8070
Harvard University

New study suggests multi-drug approach could one day make many cancers 'manageable,' Harvard researcher says

A Harvard researcher studying the evolution of drug resistance in cancer is predicting that, in a few decades, "many, many cancers could be manageable."

Martin Nowak, a Harvard Professor of Mathematics and of Biology and Director of the Program for Evolutionary Dynamics, is one of several co-authors of a paper, published in Nature, that details how resistance to targeted drug therapy emerges in colorectal cancers, and suggests a new, multi-drug approach to treatment could make many cancers manageable, if not curable, illnesses.

The key, Nowak's research suggests, is to change the way clinicians battle the disease.

Though physicians and researchers in recent years have increasingly turned to "targeted therapies" new drugs which combat cancer by interrupting its ability to grow and spread rather than traditional chemotherapy, the treatment is far from perfect. Most are only effective for a few months before the cancer evolves resistance to the drugs and is able to grow unchecked.

In the particular colon cancer treatment that was the subject of Nowak's research, the culprit is the KRAS gene. Normally responsible for producing a protein to regulate cell division, when activated, the gene helps cancer cells develop resistance to targeted therapy drugs, effectively making the treatment useless.

Based on analysis completed by Benjamin Allen, a Post-Doctoral Fellow in Mathematical Biology, and Ivana Bozic, a Post-Doctoral Fellow in Mathematics, Nowak's research suggests that, of the billions of cancer cells that exist in a patient, only a tiny percentage about one in a million are resistant to drugs used in targeted therapy. When treatment starts, the non-resistant cells are wiped out. The few resistant cells, however, quickly repopulate the cancer, causing the treatment to fail.

The answer, Nowak argued, is simple rather than the one drug used in targeted therapy, treatments must involve at least two drugs.

Nowak isn't new to such suggestions in 1995, he participated in a study, also published in Nature, that focused on the rapid evolution of drug resistance in HIV. The end result of that study, he said, was the development of the drug "cocktail" many HIV-positive patients use to help manage the disease.

Ultimately, Nowak estimated that hundreds of drugs might be needed to address all the possible treatment variations. The challenge in the near term, he said, is to develop those drugs. Once available, though, he believes the multi-drug approach offers a new avenue for cancer treatment, one that may fundamentally alter how the public views the disease.

"This will be the main avenue for research into cancer treatment, I think, for the next decade and beyond," Nowak said. "As more and more drugs are developed for targeted therapy, I think we will see a revolution in the treatment of cancer."

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For more information, visit the Harvard Gazette at: http://news.harvard.edu/gazette/story/2012/07/transforming-cancer-treatment/


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Transforming cancer treatment [ Back to EurekAlert! ] Public release date: 11-Jul-2012
[ | E-mail | Share Share ]

Contact: Peter Reuell
preuell@fas.harvard.edu
617-496-8070
Harvard University

New study suggests multi-drug approach could one day make many cancers 'manageable,' Harvard researcher says

A Harvard researcher studying the evolution of drug resistance in cancer is predicting that, in a few decades, "many, many cancers could be manageable."

Martin Nowak, a Harvard Professor of Mathematics and of Biology and Director of the Program for Evolutionary Dynamics, is one of several co-authors of a paper, published in Nature, that details how resistance to targeted drug therapy emerges in colorectal cancers, and suggests a new, multi-drug approach to treatment could make many cancers manageable, if not curable, illnesses.

The key, Nowak's research suggests, is to change the way clinicians battle the disease.

Though physicians and researchers in recent years have increasingly turned to "targeted therapies" new drugs which combat cancer by interrupting its ability to grow and spread rather than traditional chemotherapy, the treatment is far from perfect. Most are only effective for a few months before the cancer evolves resistance to the drugs and is able to grow unchecked.

In the particular colon cancer treatment that was the subject of Nowak's research, the culprit is the KRAS gene. Normally responsible for producing a protein to regulate cell division, when activated, the gene helps cancer cells develop resistance to targeted therapy drugs, effectively making the treatment useless.

Based on analysis completed by Benjamin Allen, a Post-Doctoral Fellow in Mathematical Biology, and Ivana Bozic, a Post-Doctoral Fellow in Mathematics, Nowak's research suggests that, of the billions of cancer cells that exist in a patient, only a tiny percentage about one in a million are resistant to drugs used in targeted therapy. When treatment starts, the non-resistant cells are wiped out. The few resistant cells, however, quickly repopulate the cancer, causing the treatment to fail.

The answer, Nowak argued, is simple rather than the one drug used in targeted therapy, treatments must involve at least two drugs.

Nowak isn't new to such suggestions in 1995, he participated in a study, also published in Nature, that focused on the rapid evolution of drug resistance in HIV. The end result of that study, he said, was the development of the drug "cocktail" many HIV-positive patients use to help manage the disease.

Ultimately, Nowak estimated that hundreds of drugs might be needed to address all the possible treatment variations. The challenge in the near term, he said, is to develop those drugs. Once available, though, he believes the multi-drug approach offers a new avenue for cancer treatment, one that may fundamentally alter how the public views the disease.

"This will be the main avenue for research into cancer treatment, I think, for the next decade and beyond," Nowak said. "As more and more drugs are developed for targeted therapy, I think we will see a revolution in the treatment of cancer."

###

For more information, visit the Harvard Gazette at: http://news.harvard.edu/gazette/story/2012/07/transforming-cancer-treatment/


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Source: http://www.eurekalert.org/pub_releases/2012-07/hu-tct071112.php

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How To Pay For Your New Guttering - Low Interest Loans Hub

Thursday, July 12th, 2012 at 12:06 am ?

There comes a time in every homeowner?s life when home improvements must be done, and replacing the guttering is usually on the list. Well making the first step of deciding to do so is a great way to go but then the next big question arises? how do you intend to pay for it? Any home improvements that you decide to do aren?t cheap, and it may be that you need to think about home improvement financing.

The first step to figuring out home improvement financing is to figure out what you even want to do with your house. Think about the true extent of your plans ? guttering is going to cost less than a new greenhouse and suchlike. Consider the maximum budget you have. It is only after you have considered all these that you can truly say that you are able to look at home improvement financing options.

For small jobs that will only cost a couple of hundred dollars or pounds, experts agree that you?re best just paying for it yourself with a credit card, but bigger jobs are more complex. If you are wanting some copper gutters for example, a small job like this could easily be put onto the credit card, whereas larger jobs would need finance.

If you need to head down the route of financing, it is a good idea to look at home equity loans. The benefit of a loan like this is that you simply release some of the value (equity) from your home so you can invest it back into the property. Although a great option, you need to make sure you employ a licensed contractor to do the home improvement work or you won?t qualify for the home equity loan.

You might also find that you qualify for being able to free up some cash from your life insurance fund. This plan means you only pay low interest and can have as much as 96% leant to you. Bear in mind, however, that this will reduce your death pay-out, and if you die before the loan is paid off then your loved ones won?t receive much money.

Throughout this article it is hoped that you will have found a couple of useful ideas that you can take away with you, and if you?re planning on doing more than just installing copper gutters then you will need the appropriate funds. It?s a good idea to shop around when it comes to getting finance, so that you can find the best deal.

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Source: http://lowinterestloanshub.com/low-interest-home-loans/how-to-pay-for-your-new-guttering/

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Video: Costas: Freeh report is ?damning? for Paterno

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Source: http://www.msnbc.msn.com/id/21134540/vp/48162031#48162031

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Wednesday, July 11, 2012

Video: Dick Bove: 'Safe' & 'Riskier' Ways to Play Banks

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Source: http://video.msnbc.msn.com/cnbc/48141235/

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#1: Adco 1760 White Size O Tire Cover

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Camco RV 28?-30? ULTRAGuard Class C Travel Trailer Cover is designed to protect a stored RV. It consists of a heavy duty polypropylene fabric around the sides for additional protection. This cover features triple layer SFS top panel ensuring maximum resistance to rainfall and snow. It comes with vent flaps that reduce wind lofting as well as moisture and includes a storage bag.

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Camco RV Refrigerator Vent Cover fits domestic and newer Norcold bases. It is made from UV stabilized, durable polypropylene plastic ensuring long lasting durability. This cover is easy to use and is highly durable.

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Camco 45346 RV 27? Arctic White Vinyl Spare Tire Cover

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Camco RV 27? Arctic White Vinyl Spare Tire Cover is designed to keep the dirt, rain and sun away from spare tire. It features heavy nylon thread that helps to ensure weatherproofing of seams.

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  • Wed, 11 Jul 2012 03:39:14 +0000: #4: Camping 50' Green Rope - Amazon.com: Hot New Releases in Automotive > RV Parts & Accessories
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  • Wed, 11 Jul 2012 03:39:14 +0000: #2: DM 145w Polycrystalline Solar Panel - Amazon.com: Hot New Releases in Automotive > RV Parts & Accessories
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Source: http://evernano.com/1-adco-1760-white-size-o-tire-cover/

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Star dancer born into war grows up to inspire

[ [ [['Connery is an experienced stuntman', 2]], 'http://yhoo.it/KeQd0p', '[Slideshow: See photos taken on the way down]', ' ', '630', ' ', ' ', ], [ [['Connery is an experienced stuntman', 7]], ' http://yhoo.it/KpUoHO', '[Slideshow: Death-defying daredevils]', ' ', '630', ' ', ' ', ], [ [['know that we have confidence in', 3]], 'http://yhoo.it/LqYjAX ', '[Related: The Secret Service guide to Cartagena]', ' ', '630', ' ', ' ', ], [ [['We picked up this other dog and', 5]], 'http://yhoo.it/JUSxvi', '[Related: 8 common dog fears, how to calm them]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 5]], 'http://bit.ly/JnoJYN', '[Related: Did WH share raid details with filmmakers?]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 3]], 'http://bit.ly/KoKiqJ', '[Factbox: AQAP, al-Qaeda in Yemen]', ' ', '630', ' ', ' ', ], [ [['have my contacts on or glasses', 3]], 'http://abcn.ws/KTE5AZ', '[Related: Should the murder charge be dropped?]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 5]], 'http://yhoo.it/JD7nlD', '[Related: Bristol Palin reality show debuts June 19]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 1]], 'http://bit.ly/JRPFRO', '[Related: McCain adviser who vetted Palin weighs in on VP race]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

[ [ [['did not go as far his colleague', 8]], '29438204', '0' ], [ [[' the 28-year-old neighborhood watchman who shot and killed', 4]], '28924649', '0' ], [ [['because I know God protects me', 14], ['Brian Snow was at a nearby credit union', 5]], '28811216', '0' ], [ [['The state news agency RIA-Novosti quoted Rosaviatsiya', 6]], '28805461', '0' ], [ [['measure all but certain to fail in the face of bipartisan', 4]], '28771014', '0' ], [ [['matter what you do in this case', 5]], '28759848', '0' ], [ [['presume laws are constitutional', 7]], '28747556', '0' ], [ [['has destroyed 15 to 25 houses', 7]], '28744868', '0' ], [ [['short answer is yes', 7]], '28746030', '0' ], [ [['opportunity to tell the real story', 7]], '28731764', '0' ], [ [['entirely respectable way to put off the searing constitutional controversy', 7]], '28723797', '0' ], [ [['point of my campaign is that big ideas matter', 9]], '28712293', '0' ], [ [['As the standoff dragged into a second day', 7]], '28687424', '0' ], [ [['French police stepped up the search', 17]], '28667224', '0' ], [ [['Seeking to elevate his candidacy back to a general', 8]], '28660934', '0' ], [ [['The tragic story of Trayvon Martin', 4]], '28647343', '0' ], [ [['Karzai will get a chance soon to express', 8]], '28630306', '0' ], [ [['powerful storms stretching', 8]], '28493546', '0' ], [ [['basic norm that death is private', 6]], '28413590', '0' ], [ [['songwriter also saw a surge in sales for her debut album', 6]], '28413590', '1', 'Watch music videos from Whitney Houston ', 'on Yahoo! Music', 'http://music.yahoo.com' ], [ [['keyword', 99999999999999999999999]], 'videoID', '1', 'overwrite-pre-description', 'overwrite-link-string', 'overwrite-link-url' ] ]

Source: http://news.yahoo.com/star-dancer-born-war-grows-inspire-162145268.html

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Tuesday, July 10, 2012

Motorola Atrix HD gets officially official on AT&T, for $99 on July 15

Motorola Atrix HD

It's big, sleek, slim and covered in Kevlar, and it's just $99 - it's the Motorola HD on AT&T.

Motorola Atrix HDYou knew it was coming, and here it is officially -- the Motorola Atrix HD on AT&T. Motorola inadvertently outed this one a week ago, but let's have another look at the specs, shall we?

  • Android 4.0 Ice Cream Sandwich
  • 1.5 GHz dual-core processor
  • 4.5-inch 1280x720 HD ColorBoost display
  • Gorilla Glass
  • 8GB on-board storage, with expandable microSD card slot
  • 1.5GHz dual-core processor
  • 8MP rear camera with LED flash and 1080p video recording, 1.3MP front facing camera
  • 1780 mAh battery
  • 1GB RAM
  • LTE
  • Smart actions.

All in all, nothing you probably weren't expecting. But the $99 price tag isn't to be ignored. That's pretty darn cheap for a new. In fact, it's pretty much AT&T's version of the Motorola RAZR. Not that that's a bad thing, and the Atrix HD changes things up a little bit by moving to on-screen buttons, which some of us have once again found ourselves in favor of. Webtop? Meh, yeah. It's there. But we'd rather see someone do something with Ubuntu for Android, quite honestly. But for a mere Benjamin, the Atrix HD's probably worth a look.

More: Motorola Atrix HD forums



Source: http://feedproxy.google.com/~r/androidcentral/~3/dkVVLYlTjG8/story01.htm

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Marissa Bronfman: Cameron Bailey Brings Mumbai to the 2012 TIFF | Part Two

In Part 2 of this interview, Bailey discusses how to change the future of Hindi cinema, which up-and-coming Indian stars to look out for and why Indian women in film have it so tough. Look out for Shah Rukh Khan, Priyanka Chopra, Vidya Balan and Frida Pinto. If you missed Part 1, find it here.

You've been coming to India at least once a year -- sometimes up to three times a year -- for almost a decade now. Where are your favorite spots in Bombay?

Bombay's a city that I know mostly from the hotel that I'm in, the places I go to see movies and the places that the people in the movie business take me. So that's essentially how I get to know the place.

I like Bandra a lot. It feels like a very cosmopolitan part of the city and I know that so much of the movie world is there. I like that there can be major movie stars' homes, like Shah Rukh Khan's, that are just a part of the hubbub of the city -- they're not big, fenced off areas like in LA.

When I was first going, I would take the auto rickshaws and the train between Churchgate and up north and it was great! It was a fun way to discover the city. I don't do that anymore but I'm glad that I started that way. I still like the life on the street in the city -- street food on Marine Drive and all of those great things, it's fun.

You've seen countless films from India -- any favorites?

Lagaan is a film that I think is great and it's epic and it's very long but I was fully engaged the whole time. I remember it played at the festival in 2001 in the year of 9/11 so there was a very dramatic connection to that film.

I remember going out to a theatre in Scarborough to see Devdas when it came out. It was a big experience to see that with a south Asian audience in a suburban Toronto theatre.

Dhobi Ghat is a film that's not exactly a Bollywood movie but a film that I feel a very strong personal connection to because I was lucky enough to see it fairly early on and be drawn into a conversation about the film with Aamir Khan and Kiran Rao and saw it before it was completed. I was able to present the world premiere here in Toronto [at TIFF 2010] and really felt connected to that film and to those filmmakers because I knew they were trying to do something different, really unique, that they hadn't done before. They were really trying to make a film that meant a lot to them personally and reflected something of the city that they live in. I think they showed Bombay, in that season especially, so well, really beautifully - you almost got a palpable feel of what it's like to live in that heat in monsoon season. I love that about the film.

2012-07-08-HPBaileywithDhobiGhatcast.jpg
Cameron Bailey (left) with the cast of 'Dhobi Ghat' at TIFF 2010.

The reason Dhobi Ghat made it to screens is because Aamir Khan financed it. These types of independent films rarely get financing -- or when they do, filmmakers are forced to compromise on their vision. Is this going to change?

My hope is that the leading Bollywood movie stars begin to take more risks in the was that Aamir Khan has -- I think that's what's going to have to drive it, because the stars have enormous power in India, more than in any other film industry.

If you look at the careers that some of the big Hollywood movie stars, that's really how they sustain a career. You can only beat people up for a living for so long! [laughter]

Do you think we need to look to up and coming actors like Abhay Deol to take on different, challenging roles? He does interesting films. [Dev D, Shanghai]

Yeah, he sure does. I think in that case what's similar is the end of the Hollywood studio system in the '50s and the rise of the new wave in the '60s who were all film school educated and then a whole generation of actors came along with that. Al Pacino, Dustin Hoffman and Warren Beaty -- these were actors who were like Abhay Deol today. They were working in independent movies -- movies that were more challenging, that were grittier, that were tougher, that were sexier in many ways than the big Hollywood movies. I think that independent world can develop stars in India the same way that it did in LA.

Who should we keep an eye on?

We've talked about Anurag [Kashyap] and I think we have to mention Kalki [Koechlin, Kashyap's wife and frequent collaborator.] There are divided views on some of her work but I think she's a really interesting presence in Indian cinema -- whatever film she's been in, she brings something really provocative to her performance. Abhay [Deol] I love -- I think he's a classic hero and anti-hero at the same time -- he looks like a badass on the screen.

I think Ajay Devgan's films are maybe a corollary to what's been happening -- they're commercial but they've got a kind of a tougher tone which some of the indie filmmakers are going to pick up on. Films that have a kind of a hero story or villain story but they're set in the world of politics, so that gives them a bit of an edge because a lot of films steer clear of that. They're not hero fantasies, I feel like he's trying to draw from social reality.

Shah Rukh Khan is a very thoughtful person. Should he find the right scripts, the right stories, I could also imagine him taking a path exactly like George Clooney has.

2012-07-08-HPBaileywithTGIYBcast.jpg
Cameron Bailey (left) with the cast of 'That Girl in Yellow Boots.'


The interview comes to a close but Bailey realizes we haven't discussed women in Indian film - a subject that's important to him.

What's your view on women in Indian cinema?

I think the lot of the Indian female movie star is a difficult one because they're typically not the leads -- they're the love interests. There are so many limits on what I think the traditional Indian audience will allow from the female stars. Much more limited than the men and much more limited than female stars in other big film industries. That's tough. You couldn't do There's Something About Mary. Even the kinds of roles that Julia Roberts has available to her -- there's no Erin Brockovich for Indian female stars, yet.

Actually, I have to disagree -- Vidya Balan's role in Kahaani was quite groundbreaking.

Yes! I was just going to say that, you're right. That's a change. So lets see more of that! These are some of the best performers on the Indian screen but the roles typically, traditionally, are so limited. So what Vidya Balan has done is cracked that open. Let's hope that continues, that it opens up to other women -- that they feel they can take those risks as well.

Why do you think Balan is the only one taking these kinds of roles [she was similarly praised for Dirty Picture.]

I don't know. Sometimes its just one individual saying, why not? I can do it, I choose to do it. I know there's a lot of caution around what projects people take and an audience can turn against you, in the course of a single picture. And all of the different conventions around what roles women play when they're single versus when they're married and the retirement when they marry.

I think Rani Mukherjee is a great actress! She's really good and she can do strong, dramatic work and comedy and all different kinds of things.

Priyanka Chopra -- a really charismatic presence, very sexy on screen but I think there's more that she could do if given the right projects. I think she's got good chops as an actor.

I know that there are divided views in India on people like Freida Pinto but I think what she's done is also a part of what needs to happen: working outside of India. Her career is entirely about working outside of India, but I think there might be a balance that some of the actresses working in Bollywood could bring as well, in terms of doing roles every now and then outside of India that are substantial roles not just a cameo or show up in a sexy outfit.

Maybe we just need more women writers. Maybe we need more writers that understand women better and can write a character for these actresses.

2012-07-08-HPKalkiKoechlinTIFF10.jpg
***


Read more from Marissa Bronfman here.


Photos: Nolan Bryant

?

Follow Marissa Bronfman on Twitter: www.twitter.com/marissabronfman

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Source: http://www.huffingtonpost.com/marissa-bronfman/cameron-bailey_b_1656723.html

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WebNewser: Does Facebook Cause Anxiety? http://t.co/oQLZrfDE

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Source: http://twitter.com/WebNewser/statuses/222436991088865282

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Monday, July 9, 2012

PFT: Harbaugh claims Moss is 49ers' best WR

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Before Sunday, I had never heard of Norman Sas. But now that I know that Sas, who recently died at 87, invented the game of electric football, his name will become part of the blend of fascination and frustration that comes to mind whenever I recall the love/hate pastime of my youth.

For anyone who grew up before the Madden game transformed video football (Intellivision had a decent, albeit flawed, version before that, with a cumbersome play-calling system and a center and nose tackle who never moved), the only alternative to arranging football cards on the floor and using a pen cap as the ball was Tudor Electric Football.

I spent some time reminiscing about the game during Monday?s PFT Live, and we included some funny videos of game play and photos of some impressive custom figures folks have made.? (By the way, I?m not in the picture accompanying this article; I found it on Flickr.com.? I looked much dorkier at that age.)

For most of us who played electric football, the experience often went something like Vikings defensive end Jim Marshall after he recovered a Billy Kilmer fumble in 1964.

Coincidentally, I recently started reading Chris Spielman?s excellent tribute to his late wife Stefanie, That?s Why I?m Here, and I got to page 55 this morning, where he mentions that he had experiences similar to the rest of us when playing (or trying to play) the game.

?I had a competitive streak to match my overwhelming desire to play in the NFL,? Spielman writes.? ?I ruined an electric football game [Vikings G.M.] Rick [Spielman] and I received for Christmas one year because the players made me mad.? They wouldn?t go where I wanted them to, so?I smashed it.?

(In fairness to the game, maybe Rick told Chris that the Ukraine is weak.)

Either way, thanks for the memories, Mr. Sas.? The good and, more often, the inherently frustrating.

Source: http://profootballtalk.nbcsports.com/2012/07/09/harbaugh-claims-moss-is-niners-best-receiver/related

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Best Buy cutting 2,400 jobs nationwide

Best Buy Co. Inc.?

According to a company statement, 1,600 of the layoffs would occur through the company?s 1,050 stores, which is an average of two employees per store. The total also includes 650 Geek Squad division employees. Best Buy?s Geek Squad services appliances and televisions in customers? homes.

The employees? last day will be Aug. 1.

In March, the Richfield, Mn.-based retailer, which has five stores in Memphis, announced plans to shut down 50 stores across the U.S., in a move that would eliminate 400 jobs. The company also announced a new store concept that would center around service, in order to compete with online retailers like Amazon.

No stores in Memphis were included on the closure list.

Source: http://feedproxy.google.com/~r/vertical_58/~3/vwKJBMSPZrQ/best-buy-cutting-2400-jobs-nationwide.html

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All that Glitters 2 Video Slot Review At Jackpot ... - Streak Gaming

All that Glitters 2 Video Slot Review At Jackpot Party? Casino

Glitz and glamour is what the newly released All That Glitters 2 Video
Slot at Jackpot Party? Casino is all about. It is a 27 line slot game with
a gems theme and powered by WMS Gaming. A number of
features are available including Cascading Reels?, wild, logo symbols
and a bonus feature symbol. The minimum bet is ?0.40
which is weird considering there are 27 pay lines, there is a breakdown
of how it works in the paytable. All wins pay from left to right.

The brightly coloured images really appeal to me, the reels
cascade and the gems drop down on the reels. When a
winning combination is formed, those symbols disappear and
additional symbols drop down in their place for a chance
to form additional winning combos. This will continue
until no further wins are created. The Win It Again meter
is displayed at the top of the slot game. All wins are
tracked and your most recent 5 are posted in the
meter. Three or more cascades award the total of
the 5 wins reflected in the win meter. A Mystery Boost
is randomly added to increase the Win It Again Total.

The Gem Cutter Feature is awarded when 3 or more
eyeglass symbols appear on the reels. The player is
asked to choose from a group of 20 uncut gems.
The stones are cut into one of the gems in the paytable.
Some stones may even reveal a two times multiplier.
Revealing an ?All? places a gem in each of your totals located
at the bottom of the screen. The goal is to complete
a full set of gemstones. Each type of gemstone has a different
value, so naturally you will be hoping to complete the diamonds
which have the greatest value.

New members can join Jackpot Party? today and get your
100% sign-up bonus. Start playing any of the exclusive
slot games now and match your first deposit up to the
value of ?200. Existing players have promotions
available to them, one of the current promos running is
Double Your Play?. You can claim a 100% match bonus
during the last full week of every month. Simply make your
first deposit in the last full week of every month and play
any receive a 100% match deposit.

Source: http://www.streakgaming.com/forum/all-glitters-2-video-slot-review-jackpot-party-casino-wms-gaming-t36923.html

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GPS for Agriculture Business Goes to Market - Tech Gadget Info

360bin.com: Online shopping Store in Pakistan. Buy Laptops ?

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Sherman's Security Blog: 30 freeware for Symbian smartphones

30 freeware for Symbian smartphones . Latest 'top 30 freeware' for all Symbian 3 smartphones . Excluding games, which tend to be a very personal taste (though there are some great free games too, if you look around).more

GPS for Agriculture Business Goes to Market | Rocky Mountain ?

Posts Related to GPS for Agriculture Business Goes to MarketHow to Plant and Grow a BusinessFarmers Use GPS TechnologyGPS Fleet Tracking ? Allowing Your Intervention in BusinessEuropean GPS Giant Poised for Asia ... more

Personal GPS Devices

The amount of individual GPS NAVIGATION products that individuals get access to is continually developing. In the beginning, the GPS NAVIGATION device had been cumbersome, which makes it difficult to suit all of them ... more

Source: http://techgadgetinfo.com/gps/gps-for-agriculture-business-goes-to-market-rocky-mountain/

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