Expression of Cancer-Testis Antigen Gene OY-TES-1 in Primary Brain

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Cancer Research

[Abstract]

Objective: To investigate the expression of Cancer-Testis Antigen gene OY-TES-1 in primary brain tumors?and to discuss the feasibility of this antigen as a vaccine for immunotherapy in brain tumors.Methods: With Reverse-Transcription Polymerase Chain Reaction ?RT-PCR?? 78 cases of primary brain tumors and 31 cases of normal tissues were tested and statistic analysis was performed.Results: The expressive rate of OY-TES-1 in primary brain tumor and normal tissue is 57.7%?45/78?and 6.5%?2/31??respectively, which showed there was significant difference between them ?P<0.05?. In a total of 78 cases of primary brain tumor, the expressive rate of the benign and malignant tumor is 70.6%?24/34?and 47.7%?21/44??respectively, with significant<WP=5>difference between them ?P<0.05?. The expression of OY-TES-1 showed no correlation with patient?s age, sex, and pathological grade of glioma between?~? and ?~ ??P>0.05?. Conclusion: Specifically higher expression of OY-TES-1in primary brain tumor suggested that OY-TES-1 might become a target antigen in immunotherapy of the brain tumor.

Title: Expression of Cancer-Testis Antigen Gene OY-TES-1 in Primary Brain Tumor

Category: Pancreatic Cancer

Filename: Expression of Cancer-Testis Antigen Gene OY-TES-1 in Primary Brain Tumor.pdf

Pages: 197

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